Pathogenesis of bacterial infections and immunity

@article{,

title = {Group I introns and RNA folding},

author = {E Westhof},

url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12440993},

isbn = {12440993},

year  = {2002},

date = {2002-01-01},

journal = {Biochem Soc Trans},

volume = {30},

number = {Pt 6},

pages = {1149-1152},

abstract = {Before the discovery of catalytic RNA, tRNA molecules were the most studied RNA molecules for understanding RNA folding. Afterwards, group I introns, because of their stability and the fact that structural folding could be monitored by following their catalytic activity, became the molecule of choice for studying RNA architecture and folding. A major advantage of group I introns for studying the catalytic activity of RNA molecules is that catalytic activity is triggered by the addition of external guanosine cofactors. The self-splicing activity can therefore be precisely controlled. Using group I introns, several RNA motifs central to RNA-RNA self-assembly and folding were discovered. The analysis of the recent X-ray structures of the rRNA subunits indicates that several motifs present in the ribosome occur also in various group I introns.},

note = {0300-5127 

Journal Article 

Review 

Review, Tutorial},

keywords = {Base Sequence  *Introns  Molecular Sequence Data  *Nucleic Acid Conformation  RNA/*chemistry  RNA Splicing  RNA, Catalytic, Unité ARN, WESTHOF},

pubstate = {published},

tppubtype = {article}

}