@article{naitza_drosophila_2002,
title = {The Drosophila immune defense against gram-negative infection requires the death protein dFADD},
author = {Silvia Naitza and Carine Rossé and Christine Kappler and Philippe Georgel and Marcia Belvin and David Gubb and Jacques Camonis and Jules A Hoffmann and Jean-Marc Reichhart},
issn = {1074-7613},
year = {2002},
date = {2002-11-01},
journal = {Immunity},
volume = {17},
number = {5},
pages = {575--581},
abstract = {Drosophila responds to Gram-negative infections by mounting an immune response that depends on components of the IMD pathway. We recently showed that imd encodes a protein with a death domain with high similarity to that of mammalian RIP. Using a two-hybrid screen in yeast, we have isolated the death protein dFADD as a molecule that associates with IMD. Our data show that loss of dFADD function renders flies highly susceptible to Gram-negative infections without affecting resistance to Gram-positive bacteria. By genetic analysis we show that dFADD acts downstream of IMD in the pathway that controls inducibility of the antibacterial peptide genes.},
keywords = {Adaptor Proteins, Animals, Carrier Proteins, Fas-Associated Death Domain Protein, Gene Expression Regulation, Gram-Negative Bacterial Infections, hoffmann, Immunity, M3i, reichhart, Signal Transducing, Signal Transduction},
pubstate = {published},
tppubtype = {article}
}
Drosophila responds to Gram-negative infections by mounting an immune response that depends on components of the IMD pathway. We recently showed that imd encodes a protein with a death domain with high similarity to that of mammalian RIP. Using a two-hybrid screen in yeast, we have isolated the death protein dFADD as a molecule that associates with IMD. Our data show that loss of dFADD function renders flies highly susceptible to Gram-negative infections without affecting resistance to Gram-positive bacteria. By genetic analysis we show that dFADD acts downstream of IMD in the pathway that controls inducibility of the antibacterial peptide genes.