Publications
2019
Rive Corvin, Reina Giacomo, Wagle Prerana, Treossi Emanuele, Palermo Vincenzo, Bianco Alberto, Delogu Lucia Gemma, Rieckher Matthias, Schumacher Björn
Improved Biocompatibility of Amino-Functionalized Graphene Oxide in Caenorhabditis elegans Journal Article
In: Small (Weinheim an Der Bergstrasse, Germany), vol. 15, no. 45, pp. e1902699, 2019, ISSN: 1613-6829.
Abstract | Links | BibTeX | Tags: amino-functionalized graphene oxide, Caenorhabditis elegans, graphene oxide, I2CT, innate immunity, Team-Bianco
@article{rive_improved_2019,
title = {Improved Biocompatibility of Amino-Functionalized Graphene Oxide in Caenorhabditis elegans},
author = {Corvin Rive and Giacomo Reina and Prerana Wagle and Emanuele Treossi and Vincenzo Palermo and Alberto Bianco and Lucia Gemma Delogu and Matthias Rieckher and Björn Schumacher},
doi = {10.1002/smll.201902699},
issn = {1613-6829},
year = {2019},
date = {2019-01-01},
journal = {Small (Weinheim an Der Bergstrasse, Germany)},
volume = {15},
number = {45},
pages = {e1902699},
abstract = {Graphene oxide (GO) holds high promise for diagnostic and therapeutic applications in nanomedicine but reportedly displays immunotoxicity, underlining the need for developing functionalized GO with improved biocompatibility. This study describes adverse effects of GO and amino-functionalized GO (GONH2 ) during Caenorhabditis elegans development and ageing upon acute or chronic exposure. Chronic GO treatment throughout the C. elegans development causes decreased fecundity and a reduction of animal size, while acute treatment does not lead to any measurable physiological decline. However, RNA-Sequencing data reveal that acute GO exposure induces innate immune gene expression. The p38 MAP kinase, PMK-1, which is a well-established master regulator of innate immunity, protects C. elegans from chronic GO toxicity, as pmk-1 mutants show reduced tissue-functionality and facultative vivipary. In a direct comparison, GONH2 exposure does not cause detrimental effects in the wild type or in pmk-1 mutants, and the innate immune response is considerably less pronounced. This work establishes enhanced biocompatibility of amino-functionalized GO in a whole-organism, emphasizing its potential as a biomedical nanomaterial.},
keywords = {amino-functionalized graphene oxide, Caenorhabditis elegans, graphene oxide, I2CT, innate immunity, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}
2010
Silverman Gary A, Whisstock James C, Bottomley Stephen P, Huntington James A, Kaiserman Dion, Luke Cliff J, Pak Stephen C, Reichhart Jean-Marc, Bird Phillip I
Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems Journal Article
In: J. Biol. Chem., vol. 285, no. 32, pp. 24299–24305, 2010, ISSN: 1083-351X.
Abstract | Links | BibTeX | Tags: Animals, Biological, Caenorhabditis elegans, Cell Death, Cell Differentiation, Cell Survival, Homeostasis, Humans, Immunity, Innate, M3i, Mice, Models, Phenotype, reichhart, Serpins, Transgenes, transgenic
@article{silverman_serpins_2010,
title = {Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems},
author = {Gary A Silverman and James C Whisstock and Stephen P Bottomley and James A Huntington and Dion Kaiserman and Cliff J Luke and Stephen C Pak and Jean-Marc Reichhart and Phillip I Bird},
doi = {10.1074/jbc.R110.112771},
issn = {1083-351X},
year = {2010},
date = {2010-08-01},
journal = {J. Biol. Chem.},
volume = {285},
number = {32},
pages = {24299--24305},
abstract = {Serpins compose the largest superfamily of peptidase inhibitors and are well known as regulators of hemostasis and thrombolysis. Studies using model organisms, from plants to vertebrates, now show that serpins and their unique inhibitory mechanism and conformational flexibility are exploited to control proteolysis in molecular pathways associated with cell survival, development, and host defense. In addition, an increasing number of non-inhibitory serpins are emerging as important elements within a diversity of biological systems by serving as chaperones, hormone transporters, or anti-angiogenic factors.},
keywords = {Animals, Biological, Caenorhabditis elegans, Cell Death, Cell Differentiation, Cell Survival, Homeostasis, Humans, Immunity, Innate, M3i, Mice, Models, Phenotype, reichhart, Serpins, Transgenes, transgenic},
pubstate = {published},
tppubtype = {article}
}