Pathogenesis of bacterial infections and immunity

@article{arquier_brain_2021,

title = {Brain adiponectin signaling controls peripheral insulin response in Drosophila},

author = {Nathalie Arquier and Marianne Bjordal and Philippe Hammann and Lauriane Kuhn and Pierre Léopold},

doi = {10.1038/s41467-021-25940-6},

issn = {2041-1723},

year  = {2021},

date = {2021-09-01},

journal = {Nature Communications},

volume = {12},

number = {1},

pages = {5633},

abstract = {The brain plays a key role in energy homeostasis, detecting nutrients, metabolites and circulating hormones from peripheral organs and integrating this information to control food intake and energy expenditure. Here, we show that a group of neurons in the Drosophila larval brain expresses the adiponectin receptor (AdipoR) and controls systemic growth and metabolism through insulin signaling. We identify glucose-regulated protein 78 (Grp78) as a circulating antagonist of AdipoR function produced by fat cells in response to dietary sugar. We further show that central AdipoR signaling inhibits peripheral Juvenile Hormone (JH) response, promoting insulin signaling. In conclusion, we identify a neuroendocrine axis whereby AdipoR-positive neurons control systemic insulin response.},

keywords = {Adiponectin, Animals, Brain, Cell Line, Drosophila melanogaster, Drosophila Proteins, Energy Metabolism, Genetically Modified, Hemolymph, Homeostasis, Insulin, Juvenile Hormones, Larva, Neurons, PPSE, Receptors, Signal Transduction},

pubstate = {published},

tppubtype = {article}

}

@article{chen2021,

title = {A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defenses},

author = {Di Chen and Arghyashree Roychowdhury-Sinha and Pragya Prakash and Xiao Lan and Wenmin Fan and Akira Goto and Jules A Hoffmann},

url = {https://www.pnas.org/content/118/12/e2100825118},

doi = {https://doi.org/10.1073/pnas.2100825118},

year  = {2021},

date = {2021-03-23},

urldate = {2021-03-23},

journal = {PNAS},

volume = {118},

number = {12},

abstract = {Oncogenic RasV12 cells [A. Simcox et al., PLoS Genet. 4, e1000142 (2008)] injected into adult males proliferated massively after a lag period of several days, and led to the demise of the flies after 2 to 3 wk. The injection induced an early massive transcriptomic response that, unexpectedly, included more than 100 genes encoding chemoreceptors of various families. The kinetics of induction and the identities of the induced genes differed markedly from the responses generated by injections of microbes. Subsequently, hundreds of genes were up-regulated, attesting to intense catabolic activities in the flies, active tracheogenesis, and cuticulogenesis, as well as stress and inflammation-type responses. At 11 d after the injections, GFP-positive oncogenic cells isolated from the host flies exhibited a markedly different transcriptomic profile from that of the host and distinct from that at the time of their injection, including in particular up-regulated expression of genes typical for cells engaged in the classical antimicrobial response of Drosophila.},

keywords = {cancer, chemoreceptor, Drosophila melanogaster, goto, hoffmann, innate immunity, M3i, RasV12},

pubstate = {published},

tppubtype = {article}

}

@article{pmid32843367,

title = {In vitro studies provide insight into effects of Đicer-2 helicase mutations in Đrosophila melanogaster},

author = {H M Donelick and L Talide and M Bellet and P J Aruscavage and E Lauret and E R G R Aguiar and J T Marques and C Meignin and B L Bass},

year  = {2020},

date = {2020-01-01},

journal = {RNA},

volume = {26},

number = {12},

pages = {1847--1861},

note = {[PubMed Central:hrefhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668257PMC7668257] [DOI:hrefhttps://dx.doi.org/10.1261/rna.077289.12010.1261/rna.077289.120] [PubMed:hrefhttps://www.ncbi.nlm.nih.gov/pubmed/2136255421362554]},

keywords = {antiviral innate immunity, Dicer-2, Drosophila melanogaster, M3i, meignin},

pubstate = {published},

tppubtype = {article}

}

@article{Martins_2019i,

title = {A Transgenic Flock House Virus Replicon Reveals an RNAi Independent Antiviral Mechanism Acting in Drosophila Follicular Somatic Cells },

author = {N Martins and A Lemoine and E Santiago and S Paro and JL Imler and C Meignin},

url = {https://www.g3journal.org/content/9/2/403.long},

doi = {10.1534/g3.118.200872},

year  = {2019},

date = {2019-02-07},

journal = { G3 (Bethesda)},

volume = {9},

number = {2},

pages = {403-412},

keywords = {antiviral immunity, Drosophila melanogaster, Follicular somatic cells, Genetics of Immunity, imler, M3i, meignin, replicon, Viral replicon},

pubstate = {published},

tppubtype = {article}

}

@article{Chamy2017,

title = {Advances in Myeloid-Like Cell Origins and Functions in the Model Organism Drosophila melanogaster},

author = {Laure El Chamy and Nicolas Matt and Jean-Marc Reichhart},

url = {http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.MCHD-0038-2016},

doi = {10.1128/microbiolspec.MCHD-0038-2016},

issn = {2165-0497},

year  = {2017},

date = {2017-01-01},

urldate = {2017-07-12},

journal = {Microbiology Spectrum},

volume = {5},

number = {1},

keywords = {Drosophila melanogaster, M3i, matt, Myeloid-Like Cell Origins, reichhart},

pubstate = {published},

tppubtype = {article}

}