Publications
2014
Servant A, Bianco A, Prato M, Kostarelos K
Graphene for multi-functional synthetic biology: the last 'zeitgeist' in nanomedicine Journal Article
In: Bioorganic & Medicinal Chemistry Letters, vol. 24, no. 7, pp. 1638–1649, 2014, ISSN: 1464-3405.
Abstract | Links | BibTeX | Tags: Antineoplastic Agents, carbon, Drug delivery, Drug Design, Graphite, I2CT, Nanomaterials, Nanomedicine, nanotechnology, Synthetic Biology, Team-Bianco
@article{servant_graphene_2014,
title = {Graphene for multi-functional synthetic biology: the last 'zeitgeist' in nanomedicine},
author = {A Servant and A Bianco and M Prato and K Kostarelos},
doi = {10.1016/j.bmcl.2014.01.051},
issn = {1464-3405},
year = {2014},
date = {2014-01-01},
journal = {Bioorganic & Medicinal Chemistry Letters},
volume = {24},
number = {7},
pages = {1638--1649},
abstract = {The high versatility of graphene has attracted significant attention in many areas of scientific research from electronics to physics and mechanics. One of the most intriguing utilisation of graphene remains however in nanomedicine and synthetic biology. In particular, the last decade has witnessed an exponential growth in the generation of novel candidate therapeutics of multiple biological activities based on graphene constructs with small molecules, such as anti-cancer drugs. In this Digest, we summarise the different synthetic strategies and routes available to fabricate these promising graphene conjugates and the opportunities for the design of multi-functional tools for synthetic biology that they offer.},
keywords = {Antineoplastic Agents, carbon, Drug delivery, Drug Design, Graphite, I2CT, Nanomaterials, Nanomedicine, nanotechnology, Synthetic Biology, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}
2011
Bianco Alberto, Kostarelos Kostas, Prato Maurizio
Making carbon nanotubes biocompatible and biodegradable Journal Article
In: Chemical Communications (Cambridge, England), vol. 47, no. 37, pp. 10182–10188, 2011, ISSN: 1364-548X.
Abstract | Links | BibTeX | Tags: Animals, Biocompatible, carbon, Coated Materials, HeLa Cells, Humans, I2CT, nanotechnology, Nanotubes, Team-Bianco
@article{bianco_making_2011,
title = {Making carbon nanotubes biocompatible and biodegradable},
author = {Alberto Bianco and Kostas Kostarelos and Maurizio Prato},
doi = {10.1039/c1cc13011k},
issn = {1364-548X},
year = {2011},
date = {2011-10-01},
journal = {Chemical Communications (Cambridge, England)},
volume = {47},
number = {37},
pages = {10182--10188},
abstract = {Carbon nanotubes are promising nanomaterials with great potential in the field of nanomedicine for both therapeutic and diagnostic applications. Different approaches have been developed to render this material biocompatible and to modulate any ensuing toxic effects. In the context of medical use, although chemically functionalised carbon nanotubes display reduced toxicity, they are still considered with scepticism due to their perceived non-biodegradability. Recently, it has been demonstrated that functionalised carbon nanotubes can be degraded by oxidative enzymes. This finding is offering a new perspective for the development of carbon nanotubes in medicine. This article highlights recent advances that can act as paradigm-shifts towards the design of biocompatible and biodegradable functionalised carbon nanotubes and allow their translation into the clinic.},
keywords = {Animals, Biocompatible, carbon, Coated Materials, HeLa Cells, Humans, I2CT, nanotechnology, Nanotubes, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}
Venturelli Enrica, Fabbro Chiara, Chaloin Olivier, Ménard-Moyon Cécilia, Smulski Cristian R, Ros Tatiana Da, Kostarelos Kostas, Prato Maurizio, Bianco Alberto
Antibody covalent immobilization on carbon nanotubes and assessment of antigen binding Journal Article
In: Small (Weinheim an Der Bergstrasse, Germany), vol. 7, no. 15, pp. 2179–2187, 2011, ISSN: 1613-6829.
Abstract | Links | BibTeX | Tags: Antibodies, Antigens, carbon, I2CT, Immobilized, Mucin-1, nanotechnology, Nanotubes, Protein Binding, Team-Bianco, Thermogravimetry
@article{venturelli_antibody_2011,
title = {Antibody covalent immobilization on carbon nanotubes and assessment of antigen binding},
author = {Enrica Venturelli and Chiara Fabbro and Olivier Chaloin and Cécilia Ménard-Moyon and Cristian R Smulski and Tatiana Da Ros and Kostas Kostarelos and Maurizio Prato and Alberto Bianco},
doi = {10.1002/smll.201100137},
issn = {1613-6829},
year = {2011},
date = {2011-08-01},
journal = {Small (Weinheim an Der Bergstrasse, Germany)},
volume = {7},
number = {15},
pages = {2179--2187},
abstract = {Controlling the covalent bonding of antibodies onto functionalized carbon nanotubes is a key step in the design and preparation of nanotube-based conjugates for targeting cancer cells. For this purpose, an anti-MUC1 antibody (Ab) is linked to both multi-walled (MWCNTs) and double-walled carbon nanotubes (DWCNTs) using different synthetic strategies. The presence of the Ab attached to the nanotubes is confirmed by gel electrophoresis and thermogravimetric analysis. Most importantly, molecular recognition of the antigen by surface plasmon resonance is able to determine similar Ab binding capacities for both Ab-DWCNTs and Ab-MWCNTs. These results are very relevant for the design of future receptor-targeting strategies using chemically functionalized carbon nanotubes.},
keywords = {Antibodies, Antigens, carbon, I2CT, Immobilized, Mucin-1, nanotechnology, Nanotubes, Protein Binding, Team-Bianco, Thermogravimetry},
pubstate = {published},
tppubtype = {article}
}
2008
Lacerda Lara, Herrero Maria A, Venner Kerrie, Bianco Alberto, Prato Maurizio, Kostarelos Kostas
Carbon-nanotube shape and individualization critical for renal excretion Journal Article
In: Small (Weinheim an Der Bergstrasse, Germany), vol. 4, no. 8, pp. 1130–1132, 2008, ISSN: 1613-6829.
Links | BibTeX | Tags: Animals, Biological Transport, carbon, Electron, Female, Glomerular Filtration Rate, I2CT, Inbred BALB C, Kidney Glomerulus, Mice, Microscopy, Nanoparticles, nanotechnology, Nanotubes, Team-Bianco, Transmission
@article{lacerda_carbon-nanotube_2008,
title = {Carbon-nanotube shape and individualization critical for renal excretion},
author = {Lara Lacerda and Maria A Herrero and Kerrie Venner and Alberto Bianco and Maurizio Prato and Kostas Kostarelos},
doi = {10.1002/smll.200800323},
issn = {1613-6829},
year = {2008},
date = {2008-08-01},
journal = {Small (Weinheim an Der Bergstrasse, Germany)},
volume = {4},
number = {8},
pages = {1130--1132},
keywords = {Animals, Biological Transport, carbon, Electron, Female, Glomerular Filtration Rate, I2CT, Inbred BALB C, Kidney Glomerulus, Mice, Microscopy, Nanoparticles, nanotechnology, Nanotubes, Team-Bianco, Transmission},
pubstate = {published},
tppubtype = {article}
}
2005
Bianco Alberto, Hoebeke Johan, Kostarelos Kostas, Prato Maurizio, Partidos Charalambos D
Carbon nanotubes: on the road to deliver Journal Article
In: Current Drug Delivery, vol. 2, no. 3, pp. 253–259, 2005, ISSN: 1567-2018.
Abstract | Links | BibTeX | Tags: carbon, CpG Islands, DNA, Drug Carriers, I2CT, nanotechnology, Team-Bianco
@article{bianco_carbon_2005,
title = {Carbon nanotubes: on the road to deliver},
author = {Alberto Bianco and Johan Hoebeke and Kostas Kostarelos and Maurizio Prato and Charalambos D Partidos},
doi = {10.2174/1567201054367959},
issn = {1567-2018},
year = {2005},
date = {2005-07-01},
journal = {Current Drug Delivery},
volume = {2},
number = {3},
pages = {253--259},
abstract = {Over the last few years, considerable advances have been made in the field of nanotechnology. The advent of carbon nanotube functionalization has paved the way for their potential application as a delivery system of diverse molecules such as peptides, proteins, plasmid DNA, and synthetic oligodeoxynucleotides. This opens new therapeutic and preventive opportunities to combat diseases. The scope of this review is to summarize our recent work in this rapidly growing field.},
keywords = {carbon, CpG Islands, DNA, Drug Carriers, I2CT, nanotechnology, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}
Bianco Alberto, Kostarelos Kostas, Partidos Charalambos D, Prato Maurizio
Biomedical applications of functionalised carbon nanotubes Journal Article
In: Chemical Communications (Cambridge, England), no. 5, pp. 571–577, 2005, ISSN: 1359-7345.
Abstract | Links | BibTeX | Tags: Antigens, carbon, Chemical, Drug Delivery Systems, Gene Transfer Techniques, Humans, I2CT, Models, Molecular Structure, nanotechnology, Nanotubes, Team-Bianco, Vaccines
@article{bianco_biomedical_2005,
title = {Biomedical applications of functionalised carbon nanotubes},
author = {Alberto Bianco and Kostas Kostarelos and Charalambos D Partidos and Maurizio Prato},
doi = {10.1039/b410943k},
issn = {1359-7345},
year = {2005},
date = {2005-01-01},
journal = {Chemical Communications (Cambridge, England)},
number = {5},
pages = {571--577},
abstract = {The organic functionalisation of carbon nanotubes can improve substantially their solubility and biocompatibility profile; as a consequence, their manipulation and integration into biological systems has become possible so that functionalised carbon nanotubes hold currently strong promise as novel systems for the delivery of drugs, antigens and genes.},
keywords = {Antigens, carbon, Chemical, Drug Delivery Systems, Gene Transfer Techniques, Humans, I2CT, Models, Molecular Structure, nanotechnology, Nanotubes, Team-Bianco, Vaccines},
pubstate = {published},
tppubtype = {article}
}
2003
Pantarotto Davide, Partidos Charalambos D, Graff Roland, Hoebeke Johan, Briand Jean-Paul, Prato Maurizio, Bianco Alberto
Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides Journal Article
In: Journal of the American Chemical Society, vol. 125, no. 20, pp. 6160–6164, 2003, ISSN: 0002-7863.
Abstract | Links | BibTeX | Tags: B-Lymphocyte, biomolecular, Capsid Proteins, carbon, Chromatography, Epitopes, Foot-and-Mouth Disease Virus, High Pressure Liquid, I2CT, nanotechnology, Nanotubes, Nuclear Magnetic Resonance, Peptide Fragments, Team-Bianco
@article{pantarotto_synthesis_2003,
title = {Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides},
author = {Davide Pantarotto and Charalambos D Partidos and Roland Graff and Johan Hoebeke and Jean-Paul Briand and Maurizio Prato and Alberto Bianco},
doi = {10.1021/ja034342r},
issn = {0002-7863},
year = {2003},
date = {2003-05-01},
journal = {Journal of the American Chemical Society},
volume = {125},
number = {20},
pages = {6160--6164},
abstract = {Carbon nanotubes (NTs) are becoming highly attractive molecules for applications in medicinal chemistry. The main problem of insolubility in aqueous media has been solved by developing a synthetic protocol that allows highly water-soluble carbon NTs to be obtained. As a result, biologically active peptides can be easily linked through a stable covalent bond to carbon NTs. We have demonstrated that a bound peptide from the foot-and-mouth disease virus, corresponding to the 141-159 region of the viral envelope protein VP1, retained the structural integrity and was recognized by monoclonal and polyclonal antibodies. In addition, this peptide-NT conjugate is immunogenic, eliciting antibody responses of the right specificity. Such a system could be greatly advantageous for diagnostic purposes and could find future applications in vaccine delivery.},
keywords = {B-Lymphocyte, biomolecular, Capsid Proteins, carbon, Chromatography, Epitopes, Foot-and-Mouth Disease Virus, High Pressure Liquid, I2CT, nanotechnology, Nanotubes, Nuclear Magnetic Resonance, Peptide Fragments, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}